For some reason, when I run Motec for the M48 on my XP machine, I get a low memory warning when I run EMP. It will load though. Many of the help pages when in MPI, post errors. This didn't happen earlier in the year and others in the xp world are stating similar findings with their DOS apps under xp. I'm assuming this changed with an OS patch, but not certain.
After spending hours with memory management mods, I tried DOSBox (from another M4/48 forum posting). Works!!!! Haven't tried usb interface yet but it appears DOSBox has some provisions for comm port connections so I'm optimistic. This might even work for my Win7 and Win8 laptops. Win7, I can use xp virtual mode (which gives same memory error, btw) but xp virtual mode is not available under Win8.
Just thought I'd share for any other M4 or M48 users that might have been impacted by the change in functionality under xp.